Zovirax

Zovirax Mechanism and Usage
Zovirax with Aciclovir active ingredient is a popular antiviral choice for the treatment of herpes labialis (cold sores), herpes simplex and herpes zoster.

Its efficiency as a topical treatment for suppressing herpes is in its highly selective effect and open-chain nucleoside structure. Thymidine kinase of the virus transforms the structure into acyclo-guanosine monophosphate. Compared with cellular thymidine kinase, it is 3000 times more efficient when it comes to phosphorylation.

Zovirax is a prodrug. It means Zovirax metabolises into an active metabolite after its taking for improved bioavailability and selectivity. Its oral bioavailability does not exceed 20 per cent with acute toxicity (LD50) greater than 1 g per each kg. In case the patient needs highly concentrated Aciclovir, intravenous injections are required. If taken orally, its concentration is the highest in the blood after an hour or two. Zovirax is also characterized by effective distribution (not more than a third part is protein-bound in the blood). Its half-life period is about three hours. Mechanisms of excretion are tubular secretion, kidneys, glomerular filtration.

Zovirax Satety Information
Zovirax interacts with cellular DNA. Consequently, it is not recommended for expectant mothers. Despite of the fact, it is regularly prescribed in such cases as no effects of teratogenic or carcinogenic nature have been reported for Zovirax.

Patients with kidney issues may be subject to much longer half-lives for Zovirax compared to people with normal kidney function. The result is high concentration of Zovirax in the blood. Among possible reactions are exhaustion, myoclonus syndrome, and confusion.

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